Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen : A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials
Joint Authors
Ahl, Jonna
Zhang, Shuyu
Skljarevski, Vladimir
Martinez, James M.
Liu, Peng
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This subgroup analysis assessed the efficacy of duloxetine in patients with chronic low back pain (CLBP) who did or did not use concomitant nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen (APAP).
Data were pooled from two 13-week randomized trials in patients with CLBP who were stratified according to NSAID/APAP use at baseline: duloxetine NSAID/APAP user (n=137), placebo NSAID/APAP user (n=82), duloxetine NSAID/APAP nonuser (n=206), and placebo NSAID/APAP nonuser (n=156).
NSAID/APAP users were those patients who took NSAID/APAP for at least 14 days per month during 3 months prior to study entry.
An analysis of covariance model that included therapy, study, baseline NSAID/APAP use (yes/no), and therapy-by-NSAID/APAP subgroup interaction was used to assess the efficacy.
The treatment-by-NSAID/APAP use interaction was not statistically significant (P=0.31) suggesting no substantial evidence of differential efficacy for duloxetine over placebo on pain reduction or improvement in physical function between concomitant NSAID/APAP users and non-users.
American Psychological Association (APA)
Skljarevski, Vladimir& Liu, Peng& Zhang, Shuyu& Ahl, Jonna& Martinez, James M.. 2012. Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen : A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461341
Modern Language Association (MLA)
Skljarevski, Vladimir…[et al.]. Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen : A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials. Pain Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-461341
American Medical Association (AMA)
Skljarevski, Vladimir& Liu, Peng& Zhang, Shuyu& Ahl, Jonna& Martinez, James M.. Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen : A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461341