Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra
Joint Authors
Hill, Lisa J.
Ramsden, David B.
Williams, Adrian C.
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-21
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Compartmentalized redox faults are common to ageing diseases.
Dietary constituents are catabolized to NAD(H) donating electrons producing proton-based bioenergy in coevolved, cross-species and cross-organ networks.
Nicotinamide and NAD deficiency from poor diet or high expenditure causes pellagra, an ageing and dementing disorder with lost robustness to infection and stress.
Nicotinamide and stress induce Nicotinamide-N-methyltransferase (NNMT) improving choline retention but consume methyl groups.
High NNMT activity is linked to Parkinson’s, cancers, and diseases of affluence.
Optimising nicotinamide and choline/methyl group availability is important for brain development and increased during our evolution raising metabolic and methylome ceilings through dietary/metabolic symbiotic means but strict energy constraints remain and life-history tradeoffs are the rule.
An optimal energy, NAD and methyl group supply, avoiding hypo and hyper-vitaminoses nicotinamide and choline, is important to healthy ageing and avoids utilising double-edged symbionts or uncontrolled autophagy or reversions to fermentation reactions in inflammatory and cancerous tissue that all redistribute NAD(P)(H), but incur high allostatic costs.
American Psychological Association (APA)
Williams, Adrian C.& Hill, Lisa J.& Ramsden, David B.. 2012. Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-461736
Modern Language Association (MLA)
Williams, Adrian C.…[et al.]. Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-24.
https://search.emarefa.net/detail/BIM-461736
American Medical Association (AMA)
Williams, Adrian C.& Hill, Lisa J.& Ramsden, David B.. Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases : Hypotheses and Lessons from Pellagra. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-24.
https://search.emarefa.net/detail/BIM-461736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461736