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Developmental and Reproductive Effects of SE5-OH : An Equol-Rich Soy-Based Ingredient
Joint Authors
Ueno, Tomomi
Matsuura, Ikuo
Burdock, George
Matulka, Ray A.
Uesugi, Tohru
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Consumption of the isoflavones daidzein, genistein, glycitein, and their structural analogues is generally considered beneficial to human health.
Equol is not found in soy, but is converted from daidzein by human gut bacterial flora.
Research indicates that between 30–50% of the population is capable of converting daidzein to equol; therefore, there has been recent development of a new equol-rich functional food that relies on bacterial conversion of daidzein to equol under strictly controlled conditions.
Therefore, a new equol-rich soy product (SE5-OH) has been developed, based on the bacterial conversion of daidzein; and its reproductive and developmental toxicity has been evaluated in a two-generation study and a developmental toxicity study with Sprague-Dawley rats at dose levels of 200, 1000, and 2000 mg/kg/day by gavage.
SE5-OH contains approximately 0.65% equol, 0.024% daidzein, 0.022% genistein, and 0.30% glycitein.
From the reproductive study, the no-observed-adverse-effect-level (NOAEL) for SE5-OH determined for both male and female rats is 1000 mg/kg/day (6.5 mg equol/kg/day).
In the developmental toxicity phase of the study, no effects by SE5-OH were found in the embryo-fetus at any of the doses tested.
The NOAEL for developmental effects of SE5-OH is 2000 mg/kg/day (13 mg equol/kg/day).
American Psychological Association (APA)
Matulka, Ray A.& Matsuura, Ikuo& Uesugi, Tohru& Ueno, Tomomi& Burdock, George. 2008. Developmental and Reproductive Effects of SE5-OH : An Equol-Rich Soy-Based Ingredient. Journal of Toxicology،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-462177
Modern Language Association (MLA)
Matulka, Ray A.…[et al.]. Developmental and Reproductive Effects of SE5-OH : An Equol-Rich Soy-Based Ingredient. Journal of Toxicology No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-462177
American Medical Association (AMA)
Matulka, Ray A.& Matsuura, Ikuo& Uesugi, Tohru& Ueno, Tomomi& Burdock, George. Developmental and Reproductive Effects of SE5-OH : An Equol-Rich Soy-Based Ingredient. Journal of Toxicology. 2008. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-462177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462177