Morphological Effects of HA on the Cell Compatibility of Electrospun HAPLGA Composite Nanofiber Scaffolds
Joint Authors
Haider, Adnan
Kang, Inn-Kyu
Gupta, Kailash Chandra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tissue engineering is faced with an uphill challenge to design a platform with appropriate topography and suitable surface chemistry, which could encourage desired cellular activities and guide bone tissue regeneration.
To develop such scaffolds, composite nanofiber scaffolds of nHA and sHA with PLGA were fabricated using electrospinning technique.
nHA was synthesized using precipitation method, whereas sHA was purchased.
The nHA and sHA were suspended in PLGA solution separately and electrospun at optimized electrospinning parameters.
The composite nanofiber scaffolds were characterized by FE-SEM, EDX analysis, TEM, XRD analysis, FTIR, and X-ray photoelectron.
The potential of the HA/PLGA composite nanofiber as bone scaffolds in terms of their bioactivity and biocompatibility was assessed by culturing the osteoblastic cells onto the composite nanofiber scaffolds.
The results from in vitro studies revealed that the nHA/PLGA composite nanofiber scaffolds showed higher cellular adhesion, proliferation, and enhanced osteogenesis performance, along with increased Ca+2 ions release compared to the sHA/PLGA composite nanofiber scaffolds and pristine PLGA nanofiber scaffold.
The results show that the structural dependent property of HA might affect its potential as bone scaffold and implantable materials in regenerative medicine and clinical tissue engineering.
American Psychological Association (APA)
Haider, Adnan& Gupta, Kailash Chandra& Kang, Inn-Kyu. 2014. Morphological Effects of HA on the Cell Compatibility of Electrospun HAPLGA Composite Nanofiber Scaffolds. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462250
Modern Language Association (MLA)
Haider, Adnan…[et al.]. Morphological Effects of HA on the Cell Compatibility of Electrospun HAPLGA Composite Nanofiber Scaffolds. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-462250
American Medical Association (AMA)
Haider, Adnan& Gupta, Kailash Chandra& Kang, Inn-Kyu. Morphological Effects of HA on the Cell Compatibility of Electrospun HAPLGA Composite Nanofiber Scaffolds. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-462250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462250