In Vivo Effects of Cagaita (Eugenia dysenterica, DC.) Leaf Extracts on Diarrhea Treatment
Joint Authors
Lima, T. B.
Grossi-de-Sa, Maria Fátima
Silva, Luciano Paulino
Leonardecz, E.
Rocha, Thales Lima
Franco, Octavio L.
Silva, Osmar Nascimento
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Eugenia dysenterica is a plant typically found in the Cerrado biome and commonly used in popular medicine due to its pharmacological properties, which include antidiarrheal, skin healing, and antimicrobial activities.
The effects of ethanolic extract, aqueous extract and infusion of E.
dysenterica leaves on intestinal motility and antidiarrheal activity were evaluated using ricin oil-induced diarrhea in rats.
At doses of 400 and 800 mg⋅Kg−1, the ethanolic extract decreased intestinal motility while the other extracts showed no significant effects.
Moreover, serum levels of chloride, magnesium, and phosphorus were also measured in rats.
Histopathologic and enzymatic analyses were also performed to investigate any toxic effect.
Animals treated with infusion, ethanolic extract, ricin oil, and loperamide presented morphological alterations in the small intestine, such as mucosa lesion, epithelial layer damage, and partial loss and/or morphological change of villi.
Furthermore, the liver showed congestion and hydropic degeneration.
Serum levels of alanine aminotransferase increased significantly in all treatments, but none rose above reference values.
In summary, our results suggest that compounds present in leaves of E.
dysenterica may have therapeutic benefits on recovery from diarrhea despite their toxic effects.
American Psychological Association (APA)
Lima, T. B.& Silva, Osmar Nascimento& Silva, Luciano Paulino& Rocha, Thales Lima& Grossi-de-Sa, Maria Fátima& Franco, Octavio L.…[et al.]. 2010. In Vivo Effects of Cagaita (Eugenia dysenterica, DC.) Leaf Extracts on Diarrhea Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462366
Modern Language Association (MLA)
Lima, T. B.…[et al.]. In Vivo Effects of Cagaita (Eugenia dysenterica, DC.) Leaf Extracts on Diarrhea Treatment. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462366
American Medical Association (AMA)
Lima, T. B.& Silva, Osmar Nascimento& Silva, Luciano Paulino& Rocha, Thales Lima& Grossi-de-Sa, Maria Fátima& Franco, Octavio L.…[et al.]. In Vivo Effects of Cagaita (Eugenia dysenterica, DC.) Leaf Extracts on Diarrhea Treatment. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462366