Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors
Joint Authors
Ivanovich, Khripko Jurii
Vitalievich, Sennikov Sergei
Alexandrovich, Khrapov Evgenii
Vladimirovna, Yakushenko Elena
Leonidovich, Filipenko Maxim
Pavlovna, Khripko Olga
L'vovich, Gelfgat Evgenii
Alexandrovich, Kozlov Vladimir
Sergeevna, Sennikova Nadegda
Anatolievna, Lopatnikova Julia
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-10-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
IL-18 has proinflammatory effects and participates in both innate and adaptive cellular and humoral immunity.
A number of SNPs that influence IL-18 production are found in the gene promoter region.
We investigated the association of SNPs in the IL-18 promoter at −607 and −137 with the level of IL-18 protein production by PBMC from healthy donors from Southwestern Siberia.
The genetic distribution of these SNPs in the promoter site was established by PCR.
IL-18 protein production was determined by ELISA.
Our results showed that PBMC from donors carrying allele 137C have lower levels of both spontaneous and LPS-stimulated IL-18 production.
In contrast, PBMC from donors carrying allele 607A showed significant increases in spontaneous and stimulated IL-18 production compared to wild type.
Our study suggests that the SNPs −607 and −137 in the promoter region of the IL-18 gene influence the level of IL-18 protein production by PBMC from healthy donors in Southwestern Siberia.
American Psychological Association (APA)
Pavlovna, Khripko Olga& Sergeevna, Sennikova Nadegda& Anatolievna, Lopatnikova Julia& Ivanovich, Khripko Jurii& Leonidovich, Filipenko Maxim& Alexandrovich, Khrapov Evgenii…[et al.]. 2008. Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-462402
Modern Language Association (MLA)
Pavlovna, Khripko Olga…[et al.]. Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors. Mediators of Inflammation No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-462402
American Medical Association (AMA)
Pavlovna, Khripko Olga& Sergeevna, Sennikova Nadegda& Anatolievna, Lopatnikova Julia& Ivanovich, Khripko Jurii& Leonidovich, Filipenko Maxim& Alexandrovich, Khrapov Evgenii…[et al.]. Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-462402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462402
