Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib
Joint Authors
Badipatla, Shanti
Niazi, Masooma
Balar, Bhavna
Nayudu, Suresh Kumar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Drug-induced liver injury (DILI) is a common clinical entity but is underreported due to various reasons.
Cyclooxygenase-2 inhibitors like Celecoxib have been proven to be associated with lesser incidence of adverse drug reactions compared to other nonsteroidal anti-inflammatory drugs (NSAID).
However, Celecoxib has been rarely reported to be associated with cholestasis and hepatitis.
We present a young Hispanic female presented with cholestatic liver chemistries who has been taking Celecoxib for 3 weeks.
Extensive workup did not support diagnosis of viral, autoimmune, or metabolic liver diseases.
Liver biopsy revealed findings suggestive of secondary sclerosing cholangitis.
Imaging studies were negative for large duct involvement, and endoscopy ruled out inflammatory bowel disease.
Liver chemistries normalized after cessation of medication.
We recommend that physician should be aware of this rare complication when prescribing Celecoxib.
American Psychological Association (APA)
Nayudu, Suresh Kumar& Badipatla, Shanti& Niazi, Masooma& Balar, Bhavna. 2013. Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-462817
Modern Language Association (MLA)
Nayudu, Suresh Kumar…[et al.]. Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib. Case Reports in Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-462817
American Medical Association (AMA)
Nayudu, Suresh Kumar& Badipatla, Shanti& Niazi, Masooma& Balar, Bhavna. Cholestatic Hepatitis with Small Duct Injury Associated with Celecoxib. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-462817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-462817