PET Imaging in Recurrent Medullary Thyroid Carcinoma
Joint Authors
Treglia, Giorgio
Giordano, Alessandro
Giovanella, Luca
Rufini, Vittoria
Salvatori, Massimo
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To perform an overview about the role of positron emission tomography (PET) or PET/computed tomography (PET/CT) using different radiopharmaceuticals in recurrent medullary thyroid carcinoma (MTC) based on biochemical findings (increased tumor marker levels after primary surgery).
Methods.
A comprehensive literature search of studies published in PubMed/MEDLINE, Scopus, and Embase databases through February 2012 regarding PET or PET/CT in patients with recurrent MTC was performed.
Results.
Twenty-nine studies comprising 714 patients with suspected recurrent MTC were retrieved.
Twenty-seven articles evaluated the role of fluorine-18-fluorodeoxyglucose (FDG) PET or PET/CT in recurrent MTC with conflicting results.
Diagnostic accuracy of FDG-PET and PET/CT increased in MTC patients with higher calcitonin and carcinoembryonic antigen values, suggesting that these imaging methods could be very useful in patients with more advanced and aggressive disease.
Eight articles evaluated the role of fluorine-18-dihydroxyphenylalanine (FDOPA) PET or PET/CT in recurrent MTC reporting promising results.
Overall, FDOPA seems to be superior but complementary compared to FDG in detecting recurrent MTC.
Few studies evaluating other PET tracers are also discussed.
Conclusions.
PET radiopharmaceuticals reflect different metabolic pathways in MTC.
FDOPA seems to be the most useful PET tracer in detecting recurrent MTC based on rising levels of tumor markers.
FDG may complement FDOPA in patients with more aggressive MTC.
American Psychological Association (APA)
Treglia, Giorgio& Rufini, Vittoria& Salvatori, Massimo& Giordano, Alessandro& Giovanella, Luca. 2012. PET Imaging in Recurrent Medullary Thyroid Carcinoma. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463562
Modern Language Association (MLA)
Treglia, Giorgio…[et al.]. PET Imaging in Recurrent Medullary Thyroid Carcinoma. International Journal of Molecular Imaging No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463562
American Medical Association (AMA)
Treglia, Giorgio& Rufini, Vittoria& Salvatori, Massimo& Giordano, Alessandro& Giovanella, Luca. PET Imaging in Recurrent Medullary Thyroid Carcinoma. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463562