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Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat
Joint Authors
Vilegas, Wagner
Almeida, Ana Cristina Alves
Toma, Walber
da Silva, Marcelo Aparecido
Abdelnur, Patrícia Verardi
Luiz-Ferreira, Anderson
Salvador, Marcos José
Takayama, Christiane
Eberlin, Marcos Nogueira
de-Faria, Felipe Meira
Dunder, Ricardo José
Souza-Brito, Alba Regina Monteiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Rhizophora mangle, the red mangrove, has long been known as a traditional medicine.
Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties.
In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R.
mangle bark extract (RM) against experimental gastric ulcer in rats.
Unib-Wh rats received pretreatment of R.
mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion.
Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured.
The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in adittion, LPO levels were reduced.
The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R.
mangle is the antioxidant property.
American Psychological Association (APA)
de-Faria, Felipe Meira& Almeida, Ana Cristina Alves& Luiz-Ferreira, Anderson& Takayama, Christiane& Dunder, Ricardo José& da Silva, Marcelo Aparecido…[et al.]. 2012. Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463789
Modern Language Association (MLA)
de-Faria, Felipe Meira…[et al.]. Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463789
American Medical Association (AMA)
de-Faria, Felipe Meira& Almeida, Ana Cristina Alves& Luiz-Ferreira, Anderson& Takayama, Christiane& Dunder, Ricardo José& da Silva, Marcelo Aparecido…[et al.]. Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463789