Cigarette Smoking Is Associated with Prolongation of the QTc Interval Duration in Patients with Type 2 Diabetes Mellitus
Joint Authors
Makrilakis, Konstantinos
Vlahodimitris, Ioannis
Liatis, Stavros
Stathi, Chryssoula
Katsilambros, Nicholas L.
Kalopita, Stavroula
Thomakos, Petros
Tentolouris, Nicholas
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
Aim of the study was to evaluate the effect of smoking on autonomic nervous system (ANS) activity and QTc interval duration in patients with Type 2 diabetes mellitus (T2DM).
Methods.
A total of 70 patients with T2DM (35 chronic smokers, 35 nonsmokers) treated with oral antidiabetic medications underwent continuous ECG Holter monitoring for 24 hours and analysis of time- and frequency-domain measures of heart rate variability (HRV).
HRV over short time was also assessed using the deep breathing test.
In addition, baroreflex sensitivity (BRS) was evaluated using the spontaneous sequence method.
The mean QTc interval was measured from the 24-hour ECG recordings.
Results.
Smokers had lower body mass index (BMI) and exhibited higher 24-hour mean heart rate.
There was no difference regarding all measures of ANS activity between the two groups.
Smokers showed increased mean QTc duration during the 24 hours (439.25±26.95 versus 425.05±23.03 ms, P=0.021) as well as in both day (439.14±24.31 ms, P=0.042) and night periods (440.91±32.30 versus 425.51±24.98 ms, P=0.033).
The association between smoking status and mean QTc interval persisted after adjusting for BMI.
Conclusions.
Cigarette smoking is associated with prolongation of the QTc interval in patients with T2DM by a mechanism independent of ANS dysfunction.
American Psychological Association (APA)
Thomakos, Petros& Liatis, Stavros& Kalopita, Stavroula& Vlahodimitris, Ioannis& Stathi, Chryssoula& Katsilambros, Nicholas L.…[et al.]. 2013. Cigarette Smoking Is Associated with Prolongation of the QTc Interval Duration in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463993
Modern Language Association (MLA)
Thomakos, Petros…[et al.]. Cigarette Smoking Is Associated with Prolongation of the QTc Interval Duration in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-463993
American Medical Association (AMA)
Thomakos, Petros& Liatis, Stavros& Kalopita, Stavroula& Vlahodimitris, Ioannis& Stathi, Chryssoula& Katsilambros, Nicholas L.…[et al.]. Cigarette Smoking Is Associated with Prolongation of the QTc Interval Duration in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-463993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-463993