![](/images/graphics-bg.png)
An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results
Joint Authors
Khanna, Dinesh
Baron, Murray
Lo, Ernest
Hudson, Marie
Weinfeld, Joanna
Furst, Daniel E.
Source
International Journal of Rheumatology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
To describe the methodology of a study designed to determine whether systemic sclerosis (SSc) patients with incident scleroderma renal crisis (SRC) on angiotensin converting enzyme (ACE) inhibitors prior to the onset of SRC have worse outcomes.
Methods.
Prospective, international cohort study of SRC subjects identified through an ongoing web-based survey.
Every second Friday afternoon, an e-mail was sent to 589 participating physicians to identify new cases of SRC.
Death or dialysis at one year after the onset of SRC will be compared in patients exposed or not to ACE inhibitors prior to the onset of SRC.
Results.
Fifteen months after the start of the survey, we had identified 76 incident cases of SRC.
Of these, 66 (87%) had a hypertensive SRC and 10 (13%) a normotensive SRC.
Twenty-two percent (22%) of the patients were on an ACE inhibitor immediately prior to the onset of the SRC.
To date, we have collected one-year follow-up data on approximately 1/3 of the cohort.
Of these, over 50% have died or remain on dialysis at one year.
Conclusion.
An international, web-based cohort study design is a feasible method of recruiting a substantial number of patients to study an infrequent vascular manifestation of SSc.
American Psychological Association (APA)
Hudson, Marie& Baron, Murray& Lo, Ernest& Weinfeld, Joanna& Furst, Daniel E.& Khanna, Dinesh. 2010. An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results. International Journal of Rheumatology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-464644
Modern Language Association (MLA)
Hudson, Marie…[et al.]. An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results. International Journal of Rheumatology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-464644
American Medical Association (AMA)
Hudson, Marie& Baron, Murray& Lo, Ernest& Weinfeld, Joanna& Furst, Daniel E.& Khanna, Dinesh. An International, Web-Based, Prospective Cohort Study to Determine Whether the Use of ACE Inhibitors prior to the Onset of Scleroderma Renal Crisis Is Associated with Worse Outcomes—Methodology and Preliminary Results. International Journal of Rheumatology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-464644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464644