Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles
Joint Authors
Sharma, Upendra Kumar
Sharma, Bhawna
Verma, Amita
Prajapati, Sunil
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The chemistry of heterocyclic compounds has been an interesting field of study for a long time.
Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development.
The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades.
The search for antiepileptic compounds with more selective activity and lower toxicity continues to be an active area of intensive investigation in medicinal chemistry.
During the recent years, there has been intense investigation of different classes of thiadiazole compounds, many of which possess extensive pharmacological activities, namely, antimicrobial activity, anticonvulsant, antifungal antidiabetic, anti-inflammatory, antioxidant, and antituberculosis activities, and so forth.
The resistance towards available drugs is rapidly becoming a major worldwide problem.
The need to design new compounds to deal with this resistance has become one of the most important areas of research today.
Thiadiazole is a versatile moiety that exhibits a wide variety of biological activities.
Thiadiazole moiety acts as “hydrogen binding domain” and “two-electron donor system.” It also acts as a constrained pharmacophore.
On the basis of the reported literature, we study here thiadiazole compounds and their synthetic methods chemistry and anticonvulsant activity.
American Psychological Association (APA)
Sharma, Bhawna& Verma, Amita& Prajapati, Sunil& Sharma, Upendra Kumar. 2013. Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles. International Journal of Medicinal Chemistry،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-464783
Modern Language Association (MLA)
Sharma, Bhawna…[et al.]. Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles. International Journal of Medicinal Chemistry No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-464783
American Medical Association (AMA)
Sharma, Bhawna& Verma, Amita& Prajapati, Sunil& Sharma, Upendra Kumar. Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles. International Journal of Medicinal Chemistry. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-464783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464783