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Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients : A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture
Joint Authors
Bartsch, H. H.
Lüdtke, Rainer
Jaroslawski, K.
Rostock, Matthias
Schroeder, Sven
Guethlin, C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs.
Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from which preliminary data showed promising results.
Methods.
In a randomized trial with a group sequential adaptive design in patients with CIPN, we compared EA (LV3, SP9, GB41, GB34, LI4, LI11, SI3, and HT3; n=14) with hydroelectric baths (HB, n=14), vitamin B1/B6 capsules (300/300 mg daily; VitB, n=15), and placebo capsules (n=17).
The statistical power in this trial was primarily calculated for proving EA only, so results of HB and VitB are pilot data.
Results.
CIPN complaints improved by 0.8±1.2 (EA), 1.7±1.7 (HB), 1.6±2.0 (VitB), and 1.3±1.3 points (placebo) on a 10-point numeric rating scale without significant difference between treatment groups or placebo.
In addition no significant differences in sensory nerve conduction studies or quality of life (EORTC QLQ-C30) were found.
Conclusions.
The used EA concept, HB, and VitB were not superior to placebo.
Since, contrary to our results, studies with different acupuncture concepts showed a positive effect on CIPN, the effect of acupuncture on CIPN remains unclear.
Further randomized, placebo controlled studies seem necessary.
This trial is registered with DRKS00004448.
American Psychological Association (APA)
Rostock, Matthias& Jaroslawski, K.& Guethlin, C.& Lüdtke, Rainer& Schroeder, Sven& Bartsch, H. H.. 2013. Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients : A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464856
Modern Language Association (MLA)
Rostock, Matthias…[et al.]. Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients : A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-464856
American Medical Association (AMA)
Rostock, Matthias& Jaroslawski, K.& Guethlin, C.& Lüdtke, Rainer& Schroeder, Sven& Bartsch, H. H.. Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients : A Four-Arm Randomized Trial on the Effectiveness of Electroacupuncture. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-464856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464856