An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients
Joint Authors
Iijima, Hiroko
Sakai, Yoshiyuki
Yoh, Kazunori
Iwata, Kazunari
Nishiguchi, Shuhei
Takashima, Tomoyuki
Hashimoto, Kenji
Aoki, Tomoko
Enomoto, Hirayuki
Ishii, Akio
Iwata, Yoshinori
Saito, Masaki
Yuri, Yukihisa
Tanaka, Hironori
Nakamura, Hideji
Aizawa, Nobuhiro
Imanishi, Hiroyasu
Ikeda, Naoto
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
In hepatitis B virus- (HBV-) positive patients, the relationship between the metabolic variables and histological degree of liver fibrosis has been poorly investigated.
Methods.
A total of 176 HBV-positive patients were assessed in whom the ratios of glycated albumin-to-glycated hemoglobin (GA/HbA1c) were calculated in order to investigate the relationship with the degree of liver fibrosis.
Results.
The GA/HbA1c ratio increased in association with the severity of fibrosis (METAVIR scores: F0-1: 2.61 ± 0.24, F2: 2.65 ± 0.24, F3: 2.74 ± 0.38, and F4: 2.91 ± 0.63).
The GA/HbA1c ratios were inversely correlated with four variables of liver function: the prothrombin time (PT) percentage (P<0.0001), platelet count (P<0.0001), albumin value (P<0.0001), and cholinesterase value (P<0.0001).
The GA/HbA1c ratio was positively correlated with two well-known markers of liver fibrosis, FIB-4 (P<0.0001) and the AST-to-platelet ratio index (APRI) (P<0.0001).
Furthermore, the GA/HbA1c showed better correlations with two variables of liver function (PT percentage and cholinesterase value) than did FIB-4 and with all four variables than did the APRI.
Conclusion.
The GA/HbA1c ratio is associated with the degree of liver fibrosis in HBV-positive patients.
American Psychological Association (APA)
Enomoto, Hirayuki& Aizawa, Nobuhiro& Nakamura, Hideji& Sakai, Yoshiyuki& Iwata, Yoshinori& Tanaka, Hironori…[et al.]. 2014. An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-465019
Modern Language Association (MLA)
Enomoto, Hirayuki…[et al.]. An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients. Gastroenterology Research and Practice No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-465019
American Medical Association (AMA)
Enomoto, Hirayuki& Aizawa, Nobuhiro& Nakamura, Hideji& Sakai, Yoshiyuki& Iwata, Yoshinori& Tanaka, Hironori…[et al.]. An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-465019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465019