In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia
Joint Authors
Giménez-Turba, Alberto
Sülsen, Valeria P.
Martino, Virginia S.
Muschietti, Liliana V.
Laurella, Laura C.
Anesini, Claudia
Gutierrez Yappu, D.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains.
The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated.
Peruvin was the most active compound on F32 strain of P.
falciparum with a 50% inhibitory concentration value (IC50) of 0.3 μg/mL (1.1 μM) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1 μM) and 1.8 μg/mL (6.4 μM)).
Fifty percent cytotoxic concentration (CC50) values (48 h) were 6.8 μg/mL (24.3 μM) and 10.0 μg/mL (37.9 μM) for psilostachyin and peruvin, respectively.
American Psychological Association (APA)
Sülsen, Valeria P.& Gutierrez Yappu, D.& Laurella, Laura C.& Anesini, Claudia& Giménez-Turba, Alberto& Martino, Virginia S.…[et al.]. 2011. In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-465184
Modern Language Association (MLA)
Sülsen, Valeria P.…[et al.]. In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-465184
American Medical Association (AMA)
Sülsen, Valeria P.& Gutierrez Yappu, D.& Laurella, Laura C.& Anesini, Claudia& Giménez-Turba, Alberto& Martino, Virginia S.…[et al.]. In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-465184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465184
