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Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria
Joint Authors
Kurtzhals, Jorgen A. L.
Goka, Bamenla Q.
Badoe, Ebenezer
Kitcher, Emmanuel
Rodrigues, Onike P.
Adjei, George O.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Plasmodium falciparum malaria, as well as certain antimalarial drugs, is associated with hearing impairment in adults.
There is little information, however, on the extent, if any, of this effect in children, and the evidence linking artemisinin combination therapies (ACTs) with hearing is inconclusive.
Methods.
Audiometry was conducted in children with uncomplicated malaria treated with artesunate-amodiaquine (n=37), artemether-lumefantrine (n=35), or amodiaquine (n=8) in Accra, Ghana.
Audiometry was repeated 3, 7, and 28 days later and after 9 months.
Audiometric thresholds were compared with those of a control group of children (n=57) from the same area.
Findings.
During the acute stage, hearing threshold levels of treated children were significantly elevated compared with controls (P<0.001).
The threshold elevations persisted up to 28 days, but no differences in hearing thresholds were evident between treated children and controls after 9 months.
The hearing thresholds of children treated with the two ACT regimens were comparable but lower than those of amodiaquine-treated children during acute illness.
Interpretation.
Malaria is the likely cause of the elevated hearing threshold levels during the acute illness, a finding that has implications for learning and development in areas of intense transmission, as well as for evaluating potential ototoxicity of new antimalarial drugs.
American Psychological Association (APA)
Adjei, George O.& Goka, Bamenla Q.& Kitcher, Emmanuel& Rodrigues, Onike P.& Badoe, Ebenezer& Kurtzhals, Jorgen A. L.. 2013. Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-465813
Modern Language Association (MLA)
Adjei, George O.…[et al.]. Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria. Journal of Tropical Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-465813
American Medical Association (AMA)
Adjei, George O.& Goka, Bamenla Q.& Kitcher, Emmanuel& Rodrigues, Onike P.& Badoe, Ebenezer& Kurtzhals, Jorgen A. L.. Reversible Audiometric Threshold Changes in Children with Uncomplicated Malaria. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-465813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465813