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Risk Factors for Age-Related Maculopathy
Joint Authors
Neelam, Kumari
Altaie, Rasha W.
Loane, Edward
O'Neill, Evelyn C.
Connell, Paul P.
Beatty, Stephen
Nolan, John M.
Keane, Pearse A.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-39, 39 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-06
Country of Publication
Egypt
No. of Pages
39
Main Subjects
Abstract EN
Age-related maculopathy (ARM) is the leading cause of blindness in the elderly.
Although beneficial therapeutic strategies have recently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder.
Epidemiologic studies have enhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions with respect to risk for this condition.
As a consequence, we saw a need to assimilate the published findings with respect to risk factors for ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies, case series, and case control studies investigating risk for this condition.
Our review shows that, to date, and across a spectrum of epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated to represent risk for this condition.
In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmental and genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an important role in the pathogenesis of this condition.
American Psychological Association (APA)
Connell, Paul P.& Keane, Pearse A.& O'Neill, Evelyn C.& Altaie, Rasha W.& Loane, Edward& Neelam, Kumari…[et al.]. 2009. Risk Factors for Age-Related Maculopathy. Journal of Ophthalmology،Vol. 2009, no. 2009, pp.1-39.
https://search.emarefa.net/detail/BIM-465831
Modern Language Association (MLA)
Connell, Paul P.…[et al.]. Risk Factors for Age-Related Maculopathy. Journal of Ophthalmology No. 2009 (2009), pp.1-39.
https://search.emarefa.net/detail/BIM-465831
American Medical Association (AMA)
Connell, Paul P.& Keane, Pearse A.& O'Neill, Evelyn C.& Altaie, Rasha W.& Loane, Edward& Neelam, Kumari…[et al.]. Risk Factors for Age-Related Maculopathy. Journal of Ophthalmology. 2009. Vol. 2009, no. 2009, pp.1-39.
https://search.emarefa.net/detail/BIM-465831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465831