Sperm Proteomics : Road to Male Fertility and Contraception
Joint Authors
Kwon, Woo-Sung
Pang, Myung-Geol
Lee, June-Sub
Rahman, Md. Saidur
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Spermatozoa are highly specialized cells that can be easily obtained and purified.
Mature spermatozoa are transcriptionally and translationally inactive and incapable of protein synthesis.
In addition, spermatozoa contain relatively higher amounts of membrane proteins compared to other cells; therefore, they are very suitable for proteomic studies.
Recently, the application of proteomic approaches such as the two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, and differential in-gel electrophoresis has identified several sperm-specific proteins.
These findings have provided a further understanding of protein functions involved in different sperm processes as well as of the differentiation of normal state from an abnormal one.
In addition, studies on the sperm proteome have demonstrated the importance of spermatozoal posttranslational modifications and their ability to induce physiological changes responsible for fertilization.
Large-scale proteomic studies to identify hundreds to thousands of sperm proteins will ultimately result in the development of novel biomarkers that may help to detect fertility, the state of complete contraception, and beyond.
Eventually, these protein biomarkers will allow for a better diagnosis of sperm dysfunctions and aid in drug development.
This paper reviews the recent scientific publications available from the PubMed database to address sperm proteomics and its potential application to characterize male fertility and contraception.
American Psychological Association (APA)
Rahman, Md. Saidur& Lee, June-Sub& Kwon, Woo-Sung& Pang, Myung-Geol. 2013. Sperm Proteomics : Road to Male Fertility and Contraception. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-465852
Modern Language Association (MLA)
Rahman, Md. Saidur…[et al.]. Sperm Proteomics : Road to Male Fertility and Contraception. International Journal of Endocrinology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-465852
American Medical Association (AMA)
Rahman, Md. Saidur& Lee, June-Sub& Kwon, Woo-Sung& Pang, Myung-Geol. Sperm Proteomics : Road to Male Fertility and Contraception. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-465852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465852