Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation : Implications in Cancer and Neurodegeneration
Joint Authors
Filomeni, Giuseppe
Di Giacomo, Giuseppina
Rizza, Salvatore
Montagna, Costanza
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-13
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
S-nitrosylation is a posttranslational modification of cysteine residues that has been frequently indicated as potential molecular mechanism governing cell response upon redox unbalance downstream of nitric oxide (over)production.
In the last years, increased levels of S-nitrosothiols (SNOs) have been tightly associated with the onset of nitroxidative stress-based pathologies (e.g., cancer and neurodegeneration), conditions in which alterations of mitochondrial homeostasis and activation of cellular processes dependent on it have been reported as well.
In this paper we aim at summarizing the current knowledge of mitochondria-related proteins undergoing S-nitrosylation and how this redox modification might impact on mitochondrial functions, whose impairment has been correlated to tumorigenesis and neuronal cell death.
In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy.
American Psychological Association (APA)
Di Giacomo, Giuseppina& Rizza, Salvatore& Montagna, Costanza& Filomeni, Giuseppe. 2012. Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation : Implications in Cancer and Neurodegeneration. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-465944
Modern Language Association (MLA)
Di Giacomo, Giuseppina…[et al.]. Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation : Implications in Cancer and Neurodegeneration. International Journal of Cell Biology No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-465944
American Medical Association (AMA)
Di Giacomo, Giuseppina& Rizza, Salvatore& Montagna, Costanza& Filomeni, Giuseppe. Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation : Implications in Cancer and Neurodegeneration. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-465944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465944