Helminth Infection Increases the Probability of Indeterminate QuantiFERON Gold in Tube Results in Pregnant Women

Joint Authors

Desta, Kassu
Howe, Rawleigh
Gebreegziabiher, Dawit
Abebe, Markos

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-02-19

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Background.

Approximately one-third of the world population is infected with M.

tuberculosis and helminths (Kariminia et al.

(2009), Walson et al.

(2010)).

Pregnancy and Helminth infection are known to suppress the TH1 response (Kariminia et al.

(2009), Elias et al.

(2006)) on which the QuantiFERON Gold in Tube (QFT-GIT) assay, that measures the released IFN-γ upon in vitro stimulation with mycobacterial antigens, relies on (Thomas et al.

(2010)).

Objective.

To determine whether QFT-GIT indeterminate result is significantly associated with helminth infection or not.

Methods.

In this cross-sectional study, eighty-five pregnant mothers were screened for parasitic and LTBI using Kato-Katz and QFT-GIT test-respectively, Result.

The prevalence of helminth infection in pregnant mothers was 23 (27%) of this 17 (20%) was due to Schistosoma mansoni.

Among the total of 85 study participants 26.8% were QFT-GIT positive and 14 (17%) had indeterminate results.

Three samples (21.4%) were randomly selected from the indeterminate QFT-GIT results and retested to check the reproducibility of the assay and remained indeterminate.

QFT-GIT indeterminate result showed significant association with helminth infection.

Conclusion.

Helminth infections were significantly associated with indeterminate QFT-GIT results in pregnant mothers.

Therefore further study is important to evaluate the possible effect of helminth infection by excluding the effect of pregnancy, as pregnancy also downregulates cellular immunity.

American Psychological Association (APA)

Gebreegziabiher, Dawit& Desta, Kassu& Howe, Rawleigh& Abebe, Markos. 2014. Helminth Infection Increases the Probability of Indeterminate QuantiFERON Gold in Tube Results in Pregnant Women. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-466120

Modern Language Association (MLA)

Gebreegziabiher, Dawit…[et al.]. Helminth Infection Increases the Probability of Indeterminate QuantiFERON Gold in Tube Results in Pregnant Women. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-466120

American Medical Association (AMA)

Gebreegziabiher, Dawit& Desta, Kassu& Howe, Rawleigh& Abebe, Markos. Helminth Infection Increases the Probability of Indeterminate QuantiFERON Gold in Tube Results in Pregnant Women. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-466120

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-466120