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The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy
Joint Authors
Wu, Jia-Ping
Yeh, Yu-Lan
Huang, Chih-Yang
Lin, Yueh-Min
Tsai, Chang-Hai
Kuo, Chia-Hua
Tsai, Fuu-Jen
Tsai, Chin-Chuan
Tzang, Bor-Show
Ho, Tsung-Jung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Liver regeneration after partial hepatectomy (PHx) is a physiological response for maintaining homeostasis.
The aim of this study is to investigate effects of Elephantopus scaber L.- (ESL-) induced liver regeneration on growth factors (HGF and IGF-1), cell cycle regulation, and apoptosis suppressed.
In this study, we fed five Chinese medicinal herbs (1 g/kg/day), Codonopsis pilosula (CP, Dangshen), Salvia miltiorrhiza Bunge (SMB, Danshen,), Bupleurum kasi (BK, Chaihu), Elephantopus scaber L.
(ESL, Teng-Khia-U), and Silymarin (Sm, 25 mg/kg) for 7 days to male Spraue-Dawley rats.
Then surgical 2/3 PHx was conducted and liver regeneration mechanisms were estimated on the following 24 hrs and 72 hrs.
The activities of growth factors (HGF and IGF-I) and cell cycle proteins were measured by Western blot and RT-PCR.
Histological analysis and apoptosis were detected by H&E stain and TUNEL.
The results showed that extraction of Elephantopus scaber L.
(ESL) and Silymarin (Sm, positive control) were increased protein expression levels of HGF and IGF-1 which leads into cell cycle.
These results suggest that the ESL plays a crucial role in cell cycle-induced liver regeneration and apoptosis.
These results suggested that the ESL plays a crucial role in cell cycle-induced liver regeneration and suppressed hepatocytes apoptosis.
American Psychological Association (APA)
Tsai, Chin-Chuan& Wu, Jia-Ping& Lin, Yueh-Min& Yeh, Yu-Lan& Ho, Tsung-Jung& Kuo, Chia-Hua…[et al.]. 2013. The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466527
Modern Language Association (MLA)
Tsai, Chin-Chuan…[et al.]. The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-466527
American Medical Association (AMA)
Tsai, Chin-Chuan& Wu, Jia-Ping& Lin, Yueh-Min& Yeh, Yu-Lan& Ho, Tsung-Jung& Kuo, Chia-Hua…[et al.]. The Effect of Elephantopus scaber L. on Liver Regeneration after Partial Hepatectomy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466527