Pediatric Renal Transplantation in a Highly Sensitised Child—8 Years On
Joint Authors
Awan, Atif
Keogan, Mary
Little, Dilly
Gill, Denis
Hickey, David
Conlon, Peter J.
Quinlan, Catherine
Waldron, Mary
Source
Case Reports in Transplantation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Highly sensitised children have markedly reduced chances of receiving a successful deceased donor renal transplant, increased risk of rejection, and decreased graft survival.
There is limited experience with the long-term followup of children who have undergone desensitization.
Following 2 failed transplants, our patient was highly sensitised.
She had some immunological response to intravenous immunoglobulin (IVIg) but this was not sustained.
We developed a protocol involving sequential therapies with rituximab, IVIg, and plasma exchange.
Immunosuppressant therapy at transplantation consisted of basiliximab, tacrolimus, mycophenolate mofetil, and steroids.
At the time of transplantation, historical crossmatch was ignored.
Current CDC crossmatch was negative, but T and B cell flow crossmatch was positive, due to donor-specific HLA Class I antibodies.
Further plasma exchange and immunoglobulin therapy were given pre- and postoperatively.
Our patient received a deceased donor-kidney-bearing HLA antigens to which she originally had antibodies, which would have precluded transplant.
The graft kidney continues to function well 8 years posttransplant.
American Psychological Association (APA)
Quinlan, Catherine& Awan, Atif& Gill, Denis& Waldron, Mary& Little, Dilly& Hickey, David…[et al.]. 2012. Pediatric Renal Transplantation in a Highly Sensitised Child—8 Years On. Case Reports in Transplantation،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-466672
Modern Language Association (MLA)
Quinlan, Catherine…[et al.]. Pediatric Renal Transplantation in a Highly Sensitised Child—8 Years On. Case Reports in Transplantation No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-466672
American Medical Association (AMA)
Quinlan, Catherine& Awan, Atif& Gill, Denis& Waldron, Mary& Little, Dilly& Hickey, David…[et al.]. Pediatric Renal Transplantation in a Highly Sensitised Child—8 Years On. Case Reports in Transplantation. 2012. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-466672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466672