Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age
Joint Authors
Hoppe, Tine Ursula
Nielsen, Susanne Dam
Valerius, Niels Henrik
Jeppesen, Dorthe Lisbeth
Ersbøll, Annette Kjær
Source
International Journal of Pediatrics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the immune function in HIV-exposed uninfected (HIV-EU) infants fed human donor milk.
Methods.
Ultrasound-obtained thymic index (Ti), T-lymphocyte subsets, and the number of infections were examined from birth to 18 months of age in 18 HIV-EU infants.
The infants were compared to a cohort of 47 term, HIV-unexposed breastfed or formula-fed infants.
Results.
The thymic size at 12 months of age was not significantly different between the HIV-EU group and the control infants (P=0.56).
At 4 months of age, the HIV-EU infants had significantly fewer infections than the control infants (P<0.001).
Furthermore, in the control group, the infants exclusively breastfed at 4 months of age had significantly fewer infections at 8 months when compared to age-matched formula-fed infants (P=0.001).
Conclusion.
HIV-EU infants fed human donor milk have normal growth of thymus and contract fewer infections than other healthy infants.
This finding along with fewer infections in exclusively breastfed infants compared to formula-fed infants supports the beneficial effect of human milk on the immune system.
We suggest, when breastfeeding is not possible, that providing human donor milk to vulnerable groups of infants will be beneficial for their maturing immune system.
American Psychological Association (APA)
Jeppesen, Dorthe Lisbeth& Ersbøll, Annette Kjær& Hoppe, Tine Ursula& Nielsen, Susanne Dam& Valerius, Niels Henrik. 2013. Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age. International Journal of Pediatrics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-466956
Modern Language Association (MLA)
Jeppesen, Dorthe Lisbeth…[et al.]. Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age. International Journal of Pediatrics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-466956
American Medical Association (AMA)
Jeppesen, Dorthe Lisbeth& Ersbøll, Annette Kjær& Hoppe, Tine Ursula& Nielsen, Susanne Dam& Valerius, Niels Henrik. Normal Thymic Size and Low Rate of Infections in Human Donor Milk Fed HIV-Exposed Uninfected Infants from Birth to 18 Months of Age. International Journal of Pediatrics. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-466956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466956