Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal

Joint Authors

Manickam, Valli
Doherty, Susan Lynette
Malabu, Usman Hammawa
Sangla, Kunwarjit Singh
Kan, George

Source

International Journal of Nephrology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-02-20

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Background.

Calcific uremic arteriolopathy (CUA) or calciphylaxis though generally noted for its high mortality, recent case reports have shown promising results using single agent therapies.

However, it is not clear whether combination therapeutic agents will improve course of the disease.

Objective.

To determine clinical outcome in subjects with CUA on multimodal treatment.

Methods.

All patients with end-stage renal failure (ESRF) at The Townsville Hospital, Australia, from April 1, 2006, to March 31, 2011, with diagnosis of CUA were retrospectively studied.

Results.

Six subjects with CUA (4 females and 2 males) were on various combination therapeutic agents comprising sodium thiosulphate, hyperbaric oxygen, prednisolone, cinacalcet, and parathyroidectomy in addition to intensified haemodialysis, specialist local wound care, and antibiotics.

The wounds failed to heal in 3 patients while 5 of the 6 subjects died; cause of death being sepsis in 3 and myocardial infarction in 2.

Conclusion.

Prognosis of CUA remains poor in spite of multimodal combination therapy.

Further prospective studies on a larger population are needed to verify our findings.

American Psychological Association (APA)

Malabu, Usman Hammawa& Manickam, Valli& Kan, George& Doherty, Susan Lynette& Sangla, Kunwarjit Singh. 2012. Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468355

Modern Language Association (MLA)

Malabu, Usman Hammawa…[et al.]. Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal. International Journal of Nephrology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-468355

American Medical Association (AMA)

Malabu, Usman Hammawa& Manickam, Valli& Kan, George& Doherty, Susan Lynette& Sangla, Kunwarjit Singh. Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468355

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-468355