Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal
Joint Authors
Manickam, Valli
Doherty, Susan Lynette
Malabu, Usman Hammawa
Sangla, Kunwarjit Singh
Kan, George
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Calcific uremic arteriolopathy (CUA) or calciphylaxis though generally noted for its high mortality, recent case reports have shown promising results using single agent therapies.
However, it is not clear whether combination therapeutic agents will improve course of the disease.
Objective.
To determine clinical outcome in subjects with CUA on multimodal treatment.
Methods.
All patients with end-stage renal failure (ESRF) at The Townsville Hospital, Australia, from April 1, 2006, to March 31, 2011, with diagnosis of CUA were retrospectively studied.
Results.
Six subjects with CUA (4 females and 2 males) were on various combination therapeutic agents comprising sodium thiosulphate, hyperbaric oxygen, prednisolone, cinacalcet, and parathyroidectomy in addition to intensified haemodialysis, specialist local wound care, and antibiotics.
The wounds failed to heal in 3 patients while 5 of the 6 subjects died; cause of death being sepsis in 3 and myocardial infarction in 2.
Conclusion.
Prognosis of CUA remains poor in spite of multimodal combination therapy.
Further prospective studies on a larger population are needed to verify our findings.
American Psychological Association (APA)
Malabu, Usman Hammawa& Manickam, Valli& Kan, George& Doherty, Susan Lynette& Sangla, Kunwarjit Singh. 2012. Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468355
Modern Language Association (MLA)
Malabu, Usman Hammawa…[et al.]. Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal. International Journal of Nephrology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-468355
American Medical Association (AMA)
Malabu, Usman Hammawa& Manickam, Valli& Kan, George& Doherty, Susan Lynette& Sangla, Kunwarjit Singh. Calcific Uremic Arteriolopathy on Multimodal Combination Therapy : Still Unmet Goal. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-468355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468355