The Role of Large-Format Histopathology in Assessing Subgross Morphological Prognostic Parameters : A Single Institution Report of 1000 Consecutive Breast Cancer Cases
Author
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Breast cancer subgross morphological parameters (disease extent, lesion distribution, and tumor size) provide significant prognostic information and guide therapeutic decisions.
Modern multimodality radiological imaging can determine these parameters with increasing accuracy in most patients.
Large-format histopathology preserves the spatial relationship of the tumor components and their relationship to the resection margins and has clear advantages over traditional routine pathology techniques.
We report a series of 1000 consecutive breast cancer cases worked up with large-format histology with detailed radiological-pathological correlation.
We confirmed that breast carcinomas often exhibit complex subgross morphology in both early and advanced stages.
Half of the cases were extensive tumors and occupied a tissue space ≥40 mm in its largest dimension.
Because both in situ and invasive tumor components may exhibit unifocal, multifocal, and diffuse lesion distribution, 17 different breast cancer growth patterns can be observed.
Combining in situ and invasive tumor components, most cases fall into three aggregate growth patterns: unifocal (36%), multifocal (35%), and diffuse (28%).
Large-format histology categories of tumor size and disease extent were concordant with radiological measurements in approximately 80% of the cases.
Noncalcified, low-grade in situ foci, and invasive tumor foci <5 mm were the most frequent causes of discrepant findings.
American Psychological Association (APA)
Tot, Tibor. 2012. The Role of Large-Format Histopathology in Assessing Subgross Morphological Prognostic Parameters : A Single Institution Report of 1000 Consecutive Breast Cancer Cases. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-468757
Modern Language Association (MLA)
Tot, Tibor. The Role of Large-Format Histopathology in Assessing Subgross Morphological Prognostic Parameters : A Single Institution Report of 1000 Consecutive Breast Cancer Cases. International Journal of Breast Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-468757
American Medical Association (AMA)
Tot, Tibor. The Role of Large-Format Histopathology in Assessing Subgross Morphological Prognostic Parameters : A Single Institution Report of 1000 Consecutive Breast Cancer Cases. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-468757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468757