Contribution of 18F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours : First Clinical Experience
Joint Authors
Graf, Reinhold
Fahdt, Daniel
Nyuyki, Fonyuy
Plotkin, Michail
Budach, Volker
Wust, Peter
Wurm, Reinhard
Brenner, Winfried
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Increased amino acid uptake has been demonstrated in intracerebral tumours and head and neck carcinomas of squamous cell origin.
We investigated the potential impact of using 18F-fluoro-ethyl-tyrosine (18F-FET)-PET/CT in addition to conventional imaging for gross tumour volume (GTV) delineation in stereotactic radiotherapy of skull base tumours.
The study population consisted of 14 consecutive patients with cranial base tumours (10 with squamous cell histology, 4 others).
All patients underwent a FET-PET/CT examination in addition to contrast-enhanced CT and 11 patients underwent MRI.
All tumours and histologic types showed increased FET uptake.
The GTV was defined by all voxels showing hyperintensity in MRI or CT (GTVMRI/CT) or enhancement in PET (GTVPET), forming a GTVcomposite that was used for the initial treatment fields.
An additional volume of infiltrative growth outside the GTVMRI/CT of about 1.0 ± 2 cm3 (5% of the conventional volume) was demonstrated by FET-PET only (GTVPETplus) with significant enlargement (>10% of GTVMRI/CT) in three patients.
From existing data, we found correlation between cellular density and the standardized uptake value (SUV) of FET.
We were able to substantially reduce the volume of escalated radiation dose (GTVboost) by 11 ± 2 cm3 (24%) of the conventional volume.
American Psychological Association (APA)
Graf, Reinhold& Plotkin, Michail& Nyuyki, Fonyuy& Wust, Peter& Wurm, Reinhard& Budach, Volker…[et al.]. 2012. Contribution of 18F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours : First Clinical Experience. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-470076
Modern Language Association (MLA)
Graf, Reinhold…[et al.]. Contribution of 18F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours : First Clinical Experience. International Journal of Molecular Imaging No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-470076
American Medical Association (AMA)
Graf, Reinhold& Plotkin, Michail& Nyuyki, Fonyuy& Wust, Peter& Wurm, Reinhard& Budach, Volker…[et al.]. Contribution of 18F-Fluoro-ethyl-tyrosine Positron Emission Tomography to Target Volume Delineation in Stereotactic Radiotherapy of Malignant Cranial Base Tumours : First Clinical Experience. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-470076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470076