Role of PPARα in the Control of Torpor through FGF21-NPY Pathway : From Circadian Clock to Seasonal Change in Mammals
Author
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In nature, hibernating animals encounter fasting, cold temperature and short day seasonally.
Torpor is a state of decreased physiological activity in an animal, usually characterized by a reduced body temperature and rate of metabolism to adapt such a severe environment.
Ablation of the central clock synchronizer, the suprachiasmatic nucleus in brain, abolishes torpor, a hibernation-like state, implicating the circadian clock involved in this seasonal change.
Biologists knows well the energy source of daily heterotherms/hibernators changed from glucose to lipids in winter.
Here we review several lines of evidence of a master transcriptional regulator in lipid catabolism, PPARα, in the control of torpor through FGF21-NPY pathway.
This indicate the importance of circadian—and photoperiod—regulation of PPARα to tell seasons in our body.
American Psychological Association (APA)
Ishida, Norio. 2009. Role of PPARα in the Control of Torpor through FGF21-NPY Pathway : From Circadian Clock to Seasonal Change in Mammals. PPAR Research،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-470125
Modern Language Association (MLA)
Ishida, Norio. Role of PPARα in the Control of Torpor through FGF21-NPY Pathway : From Circadian Clock to Seasonal Change in Mammals. PPAR Research No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-470125
American Medical Association (AMA)
Ishida, Norio. Role of PPARα in the Control of Torpor through FGF21-NPY Pathway : From Circadian Clock to Seasonal Change in Mammals. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-470125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470125