The Impact of Hyperglycemia on Risk of Severe Infections during Early Period of Induction Therapy in Patients with Newly Diagnosed Multiple Myeloma
Joint Authors
Kim, Yeo-Kyeoung
Jung, Sung-Hoon
Jang, Hee-Chang
Lee, Seung-Shin
Ahn, Jae-Sook
Yang, Deok-Hwan
Lee, Je-Jung
Kim, Hyeoung-Joon
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The association between hyperglycemia and infections during induction chemotherapy has been reported in a number of hematologic disorders.
This retrospective study evaluated the incidence of hyperglycemia during induction therapy in 155 patients with newly diagnosed multiple myeloma (MM) and its effect on serious infections during the first 60 days of induction.
A total of 20 (12.9%) patients developed overt hyperglycemia (≥200 mg/dL) during induction therapy.
Serious infections occurred in 28 (18.1%) of 155 patients and infection-related mortality within 2 months after treatment was 0.6% (1 patient).
In a univariate analysis, overt hyperglycemia, poor performance status (≥2), International Staging System III, lymphopenia (<500/μL), and elevated serum creatinine (≥2 mg/dL) were found to be associated with serious infections.
In multivariate analysis, only overt hyperglycemia (HR 7.846, 95% CI 2.512–24.503, P<0.001) and poor performance status (HR 5.801, 95% CI 1.974–17.050, P=0.001) remained significant.
In conclusion, this study demonstrated an association between hyperglycemia and serious infections during induction therapy in patients with MM.
American Psychological Association (APA)
Jung, Sung-Hoon& Jang, Hee-Chang& Lee, Seung-Shin& Ahn, Jae-Sook& Yang, Deok-Hwan& Kim, Yeo-Kyeoung…[et al.]. 2014. The Impact of Hyperglycemia on Risk of Severe Infections during Early Period of Induction Therapy in Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-470144
Modern Language Association (MLA)
Jung, Sung-Hoon…[et al.]. The Impact of Hyperglycemia on Risk of Severe Infections during Early Period of Induction Therapy in Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-470144
American Medical Association (AMA)
Jung, Sung-Hoon& Jang, Hee-Chang& Lee, Seung-Shin& Ahn, Jae-Sook& Yang, Deok-Hwan& Kim, Yeo-Kyeoung…[et al.]. The Impact of Hyperglycemia on Risk of Severe Infections during Early Period of Induction Therapy in Patients with Newly Diagnosed Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-470144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470144