Integrative Genomics with Mediation Analysis in a Survival Context
Joint Authors
Danielsson, Anna
Helou, Khalil
Einbeigi, Zakaria
Nemes, Szilárd
Parris, Toshima Z.
Jonasson, Junmei Miao
Steineck, Gunnar
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
DNA copy number aberrations (DCNA) and subsequent altered gene expression profiles may have a major impact on tumor initiation, on development, and eventually on recurrence and cancer-specific mortality.
However, most methods employed in integrative genomic analysis of the two biological levels, DNA and RNA, do not consider survival time.
In the present note, we propose the adoption of a survival analysis-based framework for the integrative analysis of DCNA and mRNA levels to reveal their implication on patient clinical outcome with the prerequisite that the effect of DCNA on survival is mediated by mRNA levels.
The specific aim of the paper is to offer a feasible framework to test the DCNA-mRNA-survival pathway.
We provide statistical inference algorithms for mediation based on asymptotic results.
Furthermore, we illustrate the applicability of the method in an integrative genomic analysis setting by using a breast cancer data set consisting of 141 invasive breast tumors.
In addition, we provide implementation in R.
American Psychological Association (APA)
Nemes, Szilárd& Parris, Toshima Z.& Danielsson, Anna& Einbeigi, Zakaria& Steineck, Gunnar& Jonasson, Junmei Miao…[et al.]. 2013. Integrative Genomics with Mediation Analysis in a Survival Context. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470206
Modern Language Association (MLA)
Nemes, Szilárd…[et al.]. Integrative Genomics with Mediation Analysis in a Survival Context. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470206
American Medical Association (AMA)
Nemes, Szilárd& Parris, Toshima Z.& Danielsson, Anna& Einbeigi, Zakaria& Steineck, Gunnar& Jonasson, Junmei Miao…[et al.]. Integrative Genomics with Mediation Analysis in a Survival Context. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470206