Subacute and Reproductive Oral Toxicity Assessment of the Hydroethanolic Extract of Jacaranda decurrens Roots in Adult Male Rats
Joint Authors
Cardoso, Claudia Andrea Lima
Santos, Joyce Alencar
Arruda, Aline
Kassuya, Cândida Aparecida Leite
Piccinelli, Ana Cláudia
Arena, Arielle Cristina
Vieira, Maria do Carmo
Figueiredo de Santana Aquino, Diana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Jacaranda decurrens subsp.
symmetrifoliolata Farias & Proença (Bignoniaceae) is a species traditionally used for the treatment of inflammatory and infectious diseases.
Previous findings from our group reported scientifically that J.
decurrens has anti-inflammatory efficacy.
However, more toxicological studies are needed to support and ensure its safe use.
The present study was carried out to evaluate the toxic effects of a prolonged treatment with hydroethanolic root extract of J.
decurrens (EJD) on hematological, biochemical, and reproductive parameters in adult male rats.
The animals received by oral gavage 0; 250; 500; or 1000 mg/kg body weight of EJD for 28 days.
After the treatment, biochemical, hematological, histopathological, and reproductive parameters were analyzed.
The EJD treatment did not cause adverse effects on body weight gain, feed and water consumption, hematological and biochemical profiles, or histopathological analysis of liver and kidney.
Similarly, there were no statistically significant differences in reproductive parameters, such as sperm production, number of sperm in the epididymis, and sperm morphology.
These results demonstrate the absence of subacute toxicity as a result of the oral treatment with EJD for 28 days in adult male rats.
However, other studies should be performed to evaluate the total safety of this plant.
American Psychological Association (APA)
Santos, Joyce Alencar& Arruda, Aline& Cardoso, Claudia Andrea Lima& Vieira, Maria do Carmo& Piccinelli, Ana Cláudia& Figueiredo de Santana Aquino, Diana…[et al.]. 2013. Subacute and Reproductive Oral Toxicity Assessment of the Hydroethanolic Extract of Jacaranda decurrens Roots in Adult Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-470292
Modern Language Association (MLA)
Santos, Joyce Alencar…[et al.]. Subacute and Reproductive Oral Toxicity Assessment of the Hydroethanolic Extract of Jacaranda decurrens Roots in Adult Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-470292
American Medical Association (AMA)
Santos, Joyce Alencar& Arruda, Aline& Cardoso, Claudia Andrea Lima& Vieira, Maria do Carmo& Piccinelli, Ana Cláudia& Figueiredo de Santana Aquino, Diana…[et al.]. Subacute and Reproductive Oral Toxicity Assessment of the Hydroethanolic Extract of Jacaranda decurrens Roots in Adult Male Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-470292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470292