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Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain?
Joint Authors
Nieder, Carsten
Dalhaug, Astrid
Norum, Jan
Marienhagen, Kirsten
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Newly developed systemic treatment regimens might lead to improved survival also in the subgroup of breast cancer patients that harbour brain metastases.
In order to examine this hypothesis, a matched pairs analysis was performed that involved one group of patients, which were treated after these new drugs were introduced, and one group of patients, which were treated approximately 10 years earlier.
The two groups were well balanced for the known prognostic factors age, KPS, extracranial disease status, and recursive partitioning analysis class, as well as for the extent of brain treatment.
The results show that the use of systemic chemotherapy has increased over time, both before and after the diagnosis of brain metastases.
However, such treatment was performed nearly exclusively in those patients with brain metastases that belonged to the prognostically more favourable groups.
Survival after whole-brain radiotherapy has remained unchanged in patients without further active treatment.
It has improved in prognostically better patients and especially patients that received active treatment, where the 1-year survival rates have almost doubled.
As these patient groups were small, confirmation of the results in other series should be attempted.
Nevertheless, the present results are compatible with the hypothesis that improved systemic therapy might contribute to prolonged survival in patients with brain metastases from breast cancer.
American Psychological Association (APA)
Nieder, Carsten& Marienhagen, Kirsten& Dalhaug, Astrid& Norum, Jan. 2008. Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain?. Journal of Oncology،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-470517
Modern Language Association (MLA)
Nieder, Carsten…[et al.]. Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain?. Journal of Oncology No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-470517
American Medical Association (AMA)
Nieder, Carsten& Marienhagen, Kirsten& Dalhaug, Astrid& Norum, Jan. Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain?. Journal of Oncology. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-470517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470517