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Prevalence of Thyroid Autoimmunity in Children with Celiac Disease Compared to Healthy 12-Year Olds
Joint Authors
Svensson, Johan
Ivarsson, Anneli
Högberg, Lotta
Carlsson, Annelie
Norström, Fredrik
van der Pals, Maria
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Studies have suggested a correlation between untreated celiac disease and risk for other autoimmune diseases.
We investigated the prevalence of thyroid autoimmunity in 12-year-old children (i) with symptomatic celiac disease diagnosed and treated with a gluten-free diet, (ii) with screening-detected untreated celiac disease, and (iii) without celiac disease.
Methods.
Blood samples from 12632 children were collected.
All celiac disease cases, previously diagnosed and newly screening-detected, were identified.
Per case, 4 referents were matched.
Blood samples were analyzed for autoantibodies against thyroid peroxidase (TPOAb).
The cut-off value for TPO positivity was set to 100 U/mL.
Results.
Altogether, 335 celiac disease cases were found.
In the entire celiac disease group, 7.2% (24/335) had elevated titers of TPOAb compared to 2.8% (48/1695) of the referents.
Among the previously diagnosed celiac disease cases, 7.5% (7/93, OR 2.8, 95% CI 1.2–6.4) was TPOAb positive and among screening-detected cases, 7.0% (17/242, OR 2.6, 95% CI 1.5–4.6) was TPOAb positive.
Conclusion.
Children with celiac disease showed a higher prevalence of thyroid autoimmunity.
We could not confirm the hypothesis that untreated celiac disease is associated with increased risk of developing thyroid autoimmunity.
Early initiation of celiac disease treatment might not lower the risk for other autoimmune diseases.
American Psychological Association (APA)
van der Pals, Maria& Ivarsson, Anneli& Norström, Fredrik& Högberg, Lotta& Svensson, Johan& Carlsson, Annelie. 2014. Prevalence of Thyroid Autoimmunity in Children with Celiac Disease Compared to Healthy 12-Year Olds. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470536
Modern Language Association (MLA)
van der Pals, Maria…[et al.]. Prevalence of Thyroid Autoimmunity in Children with Celiac Disease Compared to Healthy 12-Year Olds. Autoimmune Diseases No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470536
American Medical Association (AMA)
van der Pals, Maria& Ivarsson, Anneli& Norström, Fredrik& Högberg, Lotta& Svensson, Johan& Carlsson, Annelie. Prevalence of Thyroid Autoimmunity in Children with Celiac Disease Compared to Healthy 12-Year Olds. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470536