The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients
Joint Authors
Arikan, Ender
Berkarda, Sakir
Tuglu, Cengiz
Soylu, Ali Riza
Koker, Ibrahim Hakki
Yetisyigit, Tarkan
Kunduracılar, Hakan
Umit, Hasan
Unsal, Gulbin
Tezel, Ahmet Huseyin
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy.
Matherial and Methods.
44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period.
Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck.
Serum interleukin levels were measured by ELISA method.
Results.
Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups.
Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups.
Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P<0.001).
However, there were no significant difference between osteopenic and nonosteopenic cirrhotics.
Conclusion.
According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy.
Further studies in which large number of patients involved are necessary in this field.
American Psychological Association (APA)
Soylu, Ali Riza& Tuglu, Cengiz& Arikan, Ender& Yetisyigit, Tarkan& Kunduracılar, Hakan& Koker, Ibrahim Hakki…[et al.]. 2012. The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471154
Modern Language Association (MLA)
Soylu, Ali Riza…[et al.]. The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-471154
American Medical Association (AMA)
Soylu, Ali Riza& Tuglu, Cengiz& Arikan, Ender& Yetisyigit, Tarkan& Kunduracılar, Hakan& Koker, Ibrahim Hakki…[et al.]. The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-471154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471154