Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model
Joint Authors
Xu, Qi
Kanthasamy, Anumantha G.
Reddy, Manju B.
Source
Mathematical Problems in Engineering
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Iron may play an important role in Parkinson's disease (PD) since it can induce oxidative stress-dependent neurodegeneration.
The objective of this study was to determine whether the iron chelator, phytic acid (IP6) can protect against 6-hydroxydopamine- (6-OHDA-) induced apoptosis in immortalized rat mesencephalic dopaminergic cells under normal and iron-excess conditions.
Caspase-3 activity was increased about 6-fold after 6-OHDA treatment (compared to control; P<.001) and 30 μmol/L IP6 pretreatment decreased it by 38% (P<.05).
Similarly, a 63% protection (P<.001) against 6-OHDA induced DNA fragmentation was observed with IP6 pretreatment.
Under iron-excess condition, a 6-fold increase in caspase-3 activity (P<.001) and a 42% increase in DNA fragmentation (P<.05) with 6-OHDA treatment were decreased by 41% (P<.01) and 27% (P<.05), respectively, with 30 μmol/L IP6.
Together, our data suggest that IP6 protects against 6-OHDA-induced cell apoptosis in both normal and iron-excess conditions, and IP6 may offer neuroprotection in PD.
American Psychological Association (APA)
Xu, Qi& Kanthasamy, Anumantha G.& Reddy, Manju B.. 2011. Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model. Mathematical Problems in Engineering،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471727
Modern Language Association (MLA)
Xu, Qi…[et al.]. Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model. Mathematical Problems in Engineering No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-471727
American Medical Association (AMA)
Xu, Qi& Kanthasamy, Anumantha G.& Reddy, Manju B.. Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model. Mathematical Problems in Engineering. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-471727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471727