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Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy
Joint Authors
Marrazzo, Giuseppina
Drago, Filippo
Leggio, Gian Marco
Bucolo, Claudio
Salomone, Salvatore
Platania, Chiara Bianca Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetic retinopathy is a complex condition where inflammation and oxidative stress represent crucial pathways in the pathogenesis of the disease.
Aim of the study was to investigate the effects of a fortified extract of red berries, Ginkgo biloba and white willow bark containing carnosine and α-lipoic acid in early retinal and plasma changes of streptozotocin-induced diabetic rats.
Diabetes was induced by a single streptozotocin injection in Sprague Dawley rats.
Diabetics and nondiabetic (control) rats were treated daily with the fortified extract for the ten days.
Retina samples were collected and analyzed for their TNF-α and VEGF content.
Moreover, plasma oxidative stress was evaluated by thiobarbituric acid reacting substances (TBARS).
Increased TNF-α and VEGF levels were observed in the retina of diabetic rats.
Treatment with the fortified extract significantly lowered retinal cytokine levels and suppressed diabetes-related lipid peroxidation.
These data demonstrate that the fortified extract attenuates the degree of retinal inflammation and plasma lipid peroxidation preserving the retina in early diabetic rats.
American Psychological Association (APA)
Bucolo, Claudio& Marrazzo, Giuseppina& Platania, Chiara Bianca Maria& Drago, Filippo& Leggio, Gian Marco& Salomone, Salvatore. 2013. Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-471875
Modern Language Association (MLA)
Bucolo, Claudio…[et al.]. Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy. Journal of Diabetes Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-471875
American Medical Association (AMA)
Bucolo, Claudio& Marrazzo, Giuseppina& Platania, Chiara Bianca Maria& Drago, Filippo& Leggio, Gian Marco& Salomone, Salvatore. Fortified Extract of Red Berry, Ginkgo biloba, and White Willow Bark in Experimental Early Diabetic Retinopathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-471875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471875