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Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit
Joint Authors
Moreira, Magna S. A.
Falcao, Rosangela A.
do Nascimento, Patricia L. A.
Alves de Souza, Silvana
da Matta, Carolina B. B.
da Silva, Telma M. G.
Silva, Tania Maria Sarmento
de Queiroz, Aline C.
Camara, Celso Amorim
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hyptis pectinata, popularly known in Brazil as “sambacaitá” or “canudinho,” is an aromatic shrub largely grown in the northeast of Brazil.
The leaves and bark are used in an infusion for the treatment of throat and skin inflammations, bacterial infections, pain, and cancer.
Analogues of rosmarinic acid and flavonoids were obtained from the leaves of Hyptis pectinata and consisted of two new compounds, sambacaitaric acid (1) and 3-O-methyl-sambacaitaric acid (2), and nine known compounds, rosmarinic acid (3), 3-O-methyl-rosmarinic acid (4), ethyl caffeate (5), nepetoidin A (6), nepetoidin B (7), cirsiliol (8), circimaritin (9), 7-O-methylluteolin (10), and genkwanin (11).
The structures of these compounds were determined by spectroscopic methods.
Compounds 1–5, and 7 were evaluated in vitro against the promastigote form of L.
braziliensis, and the ethanol extract.
The hexane, ethyl acetate, and methanol-water fractions were also evaluated.
The EtOH extract, the hexane extract, EtOAc, MeOH:H2O fractions; and compounds 1, 2 and 4 exhibited antileishmanial activity, and compound 1 was as potent as pentamidine.
In contrast, compounds 3, 5, and 7 did not present activity against the promastigote form of L.
braziliensis below 100 µM.
To our knowledge, compounds 1 and 2 are being described for the first time.
American Psychological Association (APA)
Falcao, Rosangela A.& do Nascimento, Patricia L. A.& Alves de Souza, Silvana& da Silva, Telma M. G.& de Queiroz, Aline C.& da Matta, Carolina B. B.…[et al.]. 2013. Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473315
Modern Language Association (MLA)
Falcao, Rosangela A.…[et al.]. Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-473315
American Medical Association (AMA)
Falcao, Rosangela A.& do Nascimento, Patricia L. A.& Alves de Souza, Silvana& da Silva, Telma M. G.& de Queiroz, Aline C.& da Matta, Carolina B. B.…[et al.]. Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-473315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473315