Complement Attack against Aspergillus and Corresponding Evasion Mechanisms
Joint Authors
Rambach, Günter
Speth, Cornelia
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Invasive aspergillosis shows a high mortality rate particularly in immunocompromised patients.
Perpetually increasing numbers of affected patients highlight the importance of a clearer understanding of interactions between innate immunity and fungi.
Innate immunity is considered to be the most significant host defence against invasive fungal infections.
Complement represents a crucial part of this first line defence and comprises direct effects against invading pathogens as well as bridging functions to other parts of the immune network.
However, despite the potency of complement to attack foreign pathogens, the prevalence of invasive fungal infections is increasing.
Two possible reasons may explain that phenomenon: First, complement activation might be insufficient for an effective antifungal defence in risk patients (due to, e.g., low complement levels, poor recognition of fungal surface, or missing interplay with other immune elements in immunocompromised patients).
On the other hand, fungi may have developed evasion strategies to avoid recognition and/or eradication by complement.
In this review, we summarize the most important interactions between Aspergillus and the complement system.
We describe the various ways of complement activation by Aspergillus and the antifungal effects of the system, and also show proven and probable mechanisms of Aspergillus for complement evasion.
American Psychological Association (APA)
Speth, Cornelia& Rambach, Günter. 2012. Complement Attack against Aspergillus and Corresponding Evasion Mechanisms. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-473608
Modern Language Association (MLA)
Speth, Cornelia& Rambach, Günter. Complement Attack against Aspergillus and Corresponding Evasion Mechanisms. Interdisciplinary Perspectives on Infectious Diseases No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-473608
American Medical Association (AMA)
Speth, Cornelia& Rambach, Günter. Complement Attack against Aspergillus and Corresponding Evasion Mechanisms. Interdisciplinary Perspectives on Infectious Diseases. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-473608
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473608