Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency
Joint Authors
Chandra, Prem
Hammoudeh, Mohammed
Abdul Wahab, Atqah
al-Khalaf, Fawziya
Allangawi, Mona
Source
International Journal of Rheumatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To study bone mineral density (BMD) in cystic fibrosis (CF) children and adults with the CFTR I1234V mutation associated with pancreatic sufficiency.
Methods.
Lumbar spine, total hip, and whole-body mineral density were measured by dual-energy radiographic absorptiometry (DEXA) scan.
Z score was used for those less than 21 years and T score was used for those 21 years or older.
Results.
Twenty-one CF patients were younger than 21 years and 5 CF patients were 21 years or older.
Mean age was 17.29 ± 4.95 years, ranging from 10 to 33 years.
The mean BMD Z scores for patients younger than 21 years were −0.69 ± 0.96 (lumbar spine = L1–L4), −0.48 ± 0.92 (total hip), and −0.38 ± 0.86 (total body).
The mean T scores for patients 21 years or older were 0.14 ± 0.7 (L1–L4), 0.38 ± 1 (total hip), and 0.52 ± 1.03 (total body).
BMD reduction less than −1 was found in 7 (26.9%) CF patients.
Vitamin D deficiency in 20 CF patients (76.9%) tended to be lower in CF patients with low BMD.
BMD was significantly correlated with FEV1; however, no significant association was observed with P.
aeruginosa colonization.
Conclusion.
BMD reduction does occur in patients with mild CFTR mutation associated with pancreatic sufficiency.
American Psychological Association (APA)
Abdul Wahab, Atqah& Hammoudeh, Mohammed& Allangawi, Mona& al-Khalaf, Fawziya& Chandra, Prem. 2014. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. International Journal of Rheumatology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473733
Modern Language Association (MLA)
Abdul Wahab, Atqah…[et al.]. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. International Journal of Rheumatology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-473733
American Medical Association (AMA)
Abdul Wahab, Atqah& Hammoudeh, Mohammed& Allangawi, Mona& al-Khalaf, Fawziya& Chandra, Prem. Bone Mineral Density in Cystic Fibrosis Patients with the CFTR I1234V Mutation in a Large Kindred Family Is Associated with Pancreatic Sufficiency. International Journal of Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-473733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473733