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Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms
Joint Authors
D'Amour, Pierre
Rousseau, Louise
Yang, Zan
Hornyak, Stephen
Cantor, Tom
Source
International Journal of Endocrinology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Rats(r) with secondary hyperparathyroidism were studied to define the relationship between vitamin D metabolites and rPTH levels measured by 3 different rat ELISAs.
Controls and renal failure (RF) rats were on a normal diet, while 2 groups on a low-calcium (-Ca) or a vitamin D-deficient (-D) diet.
RF was induced surgically.
Mild RF rats had normal calcium and 25(OH)D but reduced 1,25(OH)2D levels (P<.001) with a 2.5-fold increased in rPTH (P<.001).
Severe RF rats and those on a -Ca or -D diet had reduced calcium (P<.01) and 25(OH)D levels (P<.05), with rPTH increased by 2 (-Ca diet; P<.05), 4 (-D diet; P<.001), and 20-folds (RF; P<.001) while 1,25(OH)2D was high (-Ca diet: P<.001) or low (-D diet, RF: P<.001).
25(OH)D and 1,25(OH)2D were positively and negatively related on the -Ca and -D diets, respectively.
rPTH molecular forms behaved as expected in RF and on -Ca diet, but not on -D diet with more C-rPTH fragments when less were expected.
This may be related to the short-time course of this study compared to prior studies.
American Psychological Association (APA)
D'Amour, Pierre& Rousseau, Louise& Hornyak, Stephen& Yang, Zan& Cantor, Tom. 2011. Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474020
Modern Language Association (MLA)
D'Amour, Pierre…[et al.]. Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms. International Journal of Endocrinology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-474020
American Medical Association (AMA)
D'Amour, Pierre& Rousseau, Louise& Hornyak, Stephen& Yang, Zan& Cantor, Tom. Influence of Secondary Hyperparathyroidism Induced by Low Dietary Calcium, Vitamin D Deficiency, and Renal Failure on Circulating Rat PTH Molecular Forms. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-474020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474020