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Long-Term Outcomes for Patients with Prostate Cancer Having Intermediate and High-Risk Disease, Treated with Combination External Beam Irradiation and Brachytherapy
Joint Authors
Bostwick, David
Cash, Jennifer
Wallner, Kent
Dattoli, Michael
True, Lawrence
Sorace, Richard
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Perception remains that brachytherapy-based regimens are inappropriate for patients having increased risk of extracapsular extension (ECE).
Methods.
321 consecutive intermediate and high-risk disease patients were treated between 1/92 and 2/97 by one author (M.
Dattoli) and stratified by NCCN guidelines.
157 had intermediate-risk; 164 had high-risk disease.
All were treated using the combination EBRT/brachytherapy ± hormones.
Biochemical failure was defined using PSA >0.2 and nadir +2 at last followup.
Nonfailing patients followup was median 10.5 years.
Both biochemical data and original biopsy slides were independently rereviewed at an outside institution.
Results.
Overall actuarial freedom from biochemical progression at 16 years was 82% (89% intermediate, 74% high-risk) with failure predictors: Gleason score (P=.01) and PSA (P=.03).
Hormonal therapy did not affect failure rates (P=.14).
Conclusion.
This study helps to strengthen the rationale for brachytherapy-based regimens as being both durable and desirable treatment options for such patients.
Prospective studies are justified to confirm these positive results.
American Psychological Association (APA)
Dattoli, Michael& Wallner, Kent& True, Lawrence& Bostwick, David& Cash, Jennifer& Sorace, Richard. 2010. Long-Term Outcomes for Patients with Prostate Cancer Having Intermediate and High-Risk Disease, Treated with Combination External Beam Irradiation and Brachytherapy. Journal of Oncology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-474128
Modern Language Association (MLA)
Dattoli, Michael…[et al.]. Long-Term Outcomes for Patients with Prostate Cancer Having Intermediate and High-Risk Disease, Treated with Combination External Beam Irradiation and Brachytherapy. Journal of Oncology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-474128
American Medical Association (AMA)
Dattoli, Michael& Wallner, Kent& True, Lawrence& Bostwick, David& Cash, Jennifer& Sorace, Richard. Long-Term Outcomes for Patients with Prostate Cancer Having Intermediate and High-Risk Disease, Treated with Combination External Beam Irradiation and Brachytherapy. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-474128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474128