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The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome
Joint Authors
Zhu, Xueping
Chen, Jianhua
Chen, Weichang
Zhu, Xiaoli
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The aim of this study was to use functional magnetic resonance imaging (BOLD-fMRI) to investigate the activated region associated with visceral pain in the brains of infant rats in a model of IBS.
Sixteen newborn rats were randomized into an IBS model group and a control group.
Those in the IBS group were separated from their mothers and were mechanically immobilized and had rectal sensitization with mustard essential oil for 1 week.
The control group had no treatment.
After 2 weeks, balloon catheters were inflated with 5 or 10 mL of air in the rectums of both groups.
BOLD-fMRI was performed and the data analyzed by imaging software.
In the IBS model group, rectal stimulation with 5 mL air distension activated the anterior cingulate cortex, insula cortex (IC), prefrontal cortex (PFC), and thalamus, while 10 mL air significantly activated the ACC, IC, PFC, and thalamus in the model, but not controls.
IBS model group was hypersensitive to visceral stimulation by rectal balloon inflation.
The major brain areas participating in visceral sensation included the IC, PFC, and thalamus.
American Psychological Association (APA)
Zhu, Xueping& Zhu, Xiaoli& Chen, Weichang& Chen, Jianhua. 2014. The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-474375
Modern Language Association (MLA)
Zhu, Xueping…[et al.]. The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome. Gastroenterology Research and Practice No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-474375
American Medical Association (AMA)
Zhu, Xueping& Zhu, Xiaoli& Chen, Weichang& Chen, Jianhua. The Application of Functional Magnetic Resonance Imaging in an Infant Rat Model of Irritable Bowel Syndrome. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-474375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474375