A Simple Model to Assess the Probability of Invasion in Ductal Carcinoma In Situ of the Breast Diagnosed by Needle Biopsy
Joint Authors
Stískalová, Kateřina
Fabian, Pavel
Selingerová, Iveta
Coufal, Oldřich
Schneiderová, Monika
Krsička, Petr
Gabrielová, Lucie
Justan, Ivan
Poprach, Alexandr
Vrtělová, Pavlína
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
The aim of the study was to develop a clinical prediction model for assessing the probability of having invasive cancer in the definitive surgical resection specimen in patients with biopsy diagnosis of ductal carcinoma in situ (DCIS) of the breast, to facilitate decision making regarding axillary surgery.
Methods.
In 349 women with DCIS, predictors of invasion in the definitive resection specimen were identified.
A model to predict the probability of invasion was developed and subsequently simplified to divide patients into two risk categories.
The model’s performance was validated on another patient population.
Results.
Multivariate logistic regression revealed four independent predictors of invasion: (i) suspicious (micro)invasion in the biopsy specimen; (ii) visibility of the lesion on ultrasonography; (iii) size of the lesion on mammography >30 mm; (iv) clinical palpability of the lesion.
The actual frequency of invasion in the high-risk patient group in the test and validation population was 52.6% and 48.3%, respectively; in the low-risk group it was 16.8% and 7.1%, respectively.
Conclusion.
The model proved to have good performance.
In patients with a low probability of invasion, an axillary procedure can be omitted without a substantial risk of additional surgery.
American Psychological Association (APA)
Coufal, Oldřich& Selingerová, Iveta& Vrtělová, Pavlína& Krsička, Petr& Gabrielová, Lucie& Fabian, Pavel…[et al.]. 2014. A Simple Model to Assess the Probability of Invasion in Ductal Carcinoma In Situ of the Breast Diagnosed by Needle Biopsy. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-474943
Modern Language Association (MLA)
Coufal, Oldřich…[et al.]. A Simple Model to Assess the Probability of Invasion in Ductal Carcinoma In Situ of the Breast Diagnosed by Needle Biopsy. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-474943
American Medical Association (AMA)
Coufal, Oldřich& Selingerová, Iveta& Vrtělová, Pavlína& Krsička, Petr& Gabrielová, Lucie& Fabian, Pavel…[et al.]. A Simple Model to Assess the Probability of Invasion in Ductal Carcinoma In Situ of the Breast Diagnosed by Needle Biopsy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-474943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474943