Investigating the Feasibility of Rapid MRI for Image-Guided Motion Management in Lung Cancer Radiotherapy
Joint Authors
Loo Jr., Billy W.
Keall, Paul
Hinkle, Jacob
Sawant, Amit
Alley, Marcus
Joshi, Sarang
Vasanawala, Shreyas
Pauly, Kim Butts
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cycle-to-cycle variations in respiratory motion can cause significant geometric and dosimetric errors in the administration of lung cancer radiation therapy.
A common limitation of the current strategies for motion management is that they assume a constant, reproducible respiratory cycle.
In this work, we investigate the feasibility of using rapid MRI for providing long-term imaging of the thorax in order to better capture cycle-to-cycle variations.
Two nonsmall-cell lung cancer patients were imaged (free-breathing, no extrinsic contrast, and 1.5 T scanner).
A balanced steady-state-free-precession (b-SSFP) sequence was used to acquire cine-2D and cine-3D (4D) images.
In the case of Patient 1 (right midlobe lesion, ~40 mm diameter), tumor motion was well correlated with diaphragmatic motion.
In the case of Patient 2, (left upper-lobe lesion, ~60 mm diameter), tumor motion was poorly correlated with diaphragmatic motion.
Furthermore, the motion of the tumor centroid was poorly correlated with the motion of individual points on the tumor boundary, indicating significant rotation and/or deformation.
These studies indicate that image quality and acquisition speed of cine-2D MRI were adequate for motion monitoring.
However, significant improvements are required to achieve comparable speeds for truly 4D MRI.
Despite several challenges, rapid MRI offers a feasible and attractive tool for noninvasive, long-term motion monitoring.
American Psychological Association (APA)
Sawant, Amit& Keall, Paul& Pauly, Kim Butts& Alley, Marcus& Vasanawala, Shreyas& Loo Jr., Billy W.…[et al.]. 2014. Investigating the Feasibility of Rapid MRI for Image-Guided Motion Management in Lung Cancer Radiotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475348
Modern Language Association (MLA)
Sawant, Amit…[et al.]. Investigating the Feasibility of Rapid MRI for Image-Guided Motion Management in Lung Cancer Radiotherapy. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-475348
American Medical Association (AMA)
Sawant, Amit& Keall, Paul& Pauly, Kim Butts& Alley, Marcus& Vasanawala, Shreyas& Loo Jr., Billy W.…[et al.]. Investigating the Feasibility of Rapid MRI for Image-Guided Motion Management in Lung Cancer Radiotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-475348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475348