Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers
Joint Authors
Aviñó, Anna
Ferreira, Rubén
Gargallo, Raimundo
Eritja, Ramon
Pérez-Tomás, Ricardo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described.
Subsequent studies on cell viability showed that these compounds are not cytotoxic.
Binding to several DNA structures was studied by competitive dialysis, which showed a clear affinity for DNA sequences that form G-quadruplexes and parallel triplexes.
The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA.
These spectral changes were used to calculate the binding constants (K).
Log K were found to be in the order of 4–6.
American Psychological Association (APA)
Ferreira, Rubén& Aviñó, Anna& Pérez-Tomás, Ricardo& Gargallo, Raimundo& Eritja, Ramon. 2010. Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-475638
Modern Language Association (MLA)
Ferreira, Rubén…[et al.]. Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers. Journal of Nucleic Acids No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-475638
American Medical Association (AMA)
Ferreira, Rubén& Aviñó, Anna& Pérez-Tomás, Ricardo& Gargallo, Raimundo& Eritja, Ramon. Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-475638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475638
