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Ovarian Carcinosarcoma : Effects of Cytoreductive Status and Platinum-Based Chemotherapy on Survival
Joint Authors
Tseng, Jill H.
Nutter, Benjamin
Escobar, Pedro F.
Jernigan, Amelia M.
Rose, Peter
Fader, Amanda Nickles
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To define survival patterns of women with ovarian carcinosarcoma based on patient, tumor, and treatment characteristics.
Methods/Materials.
A single-institution, retrospective analysis of women diagnosed with ovarian carcinosarcoma from February 1993 to May 2009 was performed.
Survival was analyzed with Cox proportional hazards ratios and Kaplan Meier tests.
Results.
Forty-seven cases of primary ovarian carcinosarcoma were identified.
Age conveyed an HR 3.28 (95% CI 1.51–7.11, P=0.003) for death.
Compared to Stages I-II, Stage III carried an HR for death of 4.75 (95% CI 1.16–19.4, P=0.03) and Stage IV disease an HR of 9.13 (95% CI 1.76–47.45, P=0.009).
Compared to those with microscopic residual, women with >1 cm diameter of residual disease after primary cytoreductive surgery had an HR for death of 4.71 (95% CI 1.84–12.09, P=0.001).
At analysis, 59.1% of those who received platinum-based chemotherapy were alive, compared to 23.1% of those who received nonplatinum-based chemotherapy (P=0.08).
Conclusions.
Age, stage, and cytoreduction to no gross residual disease are associated with improved survival in women with ovarian carcinosarcoma.
Complete surgical cytoreduction should be the goal of surgical management when possible, but the ideal adjuvant treatment regimen remains unclear.
American Psychological Association (APA)
Jernigan, Amelia M.& Fader, Amanda Nickles& Nutter, Benjamin& Rose, Peter& Tseng, Jill H.& Escobar, Pedro F.. 2013. Ovarian Carcinosarcoma : Effects of Cytoreductive Status and Platinum-Based Chemotherapy on Survival. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-475773
Modern Language Association (MLA)
Jernigan, Amelia M.…[et al.]. Ovarian Carcinosarcoma : Effects of Cytoreductive Status and Platinum-Based Chemotherapy on Survival. Obstetrics and Gynecology International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-475773
American Medical Association (AMA)
Jernigan, Amelia M.& Fader, Amanda Nickles& Nutter, Benjamin& Rose, Peter& Tseng, Jill H.& Escobar, Pedro F.. Ovarian Carcinosarcoma : Effects of Cytoreductive Status and Platinum-Based Chemotherapy on Survival. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-475773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475773