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ER-Mitochondria Crosstalk during Cerebral Ischemia : Molecular Chaperones and ER-Mitochondrial Calcium Transfer
Joint Authors
Ouyang, Yi-Bing
Giffard, Rona G.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It is commonly believed that sustained elevations in the mitochondrial matrix Ca2+ concentration are a major feature of the intracellular cascade of lethal events during cerebral ischemia.
The physical association between the endoplasmic reticulum (ER) and mitochondria, known as the mitochondria-associated ER membrane (MAM), enables highly efficient transmission of Ca2+ from the ER to mitochondria under both physiological and pathological conditions.
Molecular chaperones are well known for their protective effects during cerebral ischemia.
It has been demonstrated recently that many molecular chaperones coexist with MAM and regulate the MAM and thus Ca2+ concentration inside mitochondria.
Here, we review recent research on cerebral ischemia and MAM, with a focus on molecular chaperones and ER-mitochondrial calcium transfer.
American Psychological Association (APA)
Ouyang, Yi-Bing& Giffard, Rona G.. 2012. ER-Mitochondria Crosstalk during Cerebral Ischemia : Molecular Chaperones and ER-Mitochondrial Calcium Transfer. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476112
Modern Language Association (MLA)
Ouyang, Yi-Bing& Giffard, Rona G.. ER-Mitochondria Crosstalk during Cerebral Ischemia : Molecular Chaperones and ER-Mitochondrial Calcium Transfer. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-476112
American Medical Association (AMA)
Ouyang, Yi-Bing& Giffard, Rona G.. ER-Mitochondria Crosstalk during Cerebral Ischemia : Molecular Chaperones and ER-Mitochondrial Calcium Transfer. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-476112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476112