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NOVOMIR : De Novo Prediction of MicroRNA-Coding Regions in a Single Plant-Genome
Joint Authors
Teune, Jan-Hendrik
Steger, Gerhard
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MicroRNAs (miRNA) are small regulatory, noncoding RNA molecules that are transcribed as primary miRNAs (pri-miRNA) from eukaryotic genomes.
At least in plants, their regulatory activity is mediated through base-pairing with protein-coding messenger RNAs (mRNA) followed by mRNA degradation or translation repression.
We describe NOVOMIR, a program for the identification of miRNA genes in plant genomes.
It uses a series of filter steps and a statistical model to discriminate a pre-miRNA from other RNAs and does rely neither on prior knowledge of a miRNA target nor on comparative genomics.
The sensitivity and specificity of NOVOMIR for detection of premiRNAs from Arabidopsis thaliana is ~0.83 and ~0.99, respectively.
Plant pre-miRNAs are more heterogeneous with respect to size and structure than animal pre-miRNAs.
Despite these difficulties, NOVOMIR is well suited to perform searches for pre-miRNAs on a genomic scale.
NOVOMIR is written in Perl and relies on two additional, free programs for prediction of RNA secondary structure (RNALFOLD, RNASHAPES).
American Psychological Association (APA)
Teune, Jan-Hendrik& Steger, Gerhard. 2010. NOVOMIR : De Novo Prediction of MicroRNA-Coding Regions in a Single Plant-Genome. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-476265
Modern Language Association (MLA)
Teune, Jan-Hendrik& Steger, Gerhard. NOVOMIR : De Novo Prediction of MicroRNA-Coding Regions in a Single Plant-Genome. Journal of Nucleic Acids No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-476265
American Medical Association (AMA)
Teune, Jan-Hendrik& Steger, Gerhard. NOVOMIR : De Novo Prediction of MicroRNA-Coding Regions in a Single Plant-Genome. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-476265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476265