Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status
Joint Authors
Miyazaki, Kohji
Masuda, Masanori
Tokunaga, Osamu
Takase, Yukari
Kai, Keita
Noshiro, Hirokazu
Kitahara, Kenji
Miyoshi, Atsushi
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Previous studies have investigated extrahepatic multiple primary malignancy (EHPM) associated with hepatocellular carcinoma (HCC).
However, its correlation with viral infection, such as hepatitis B virus (HBV) or hepatitis C virus (HCV), has not been examined.
The aim of this study is to investigate the association between EHPM and hepatitis infection in HCC patients.
A total of 412 patients who underwent surgical resection for primary HCC were enrolled.
Viral infection was evaluated by serum HBV surface antigen (HBs Ag) and HCV antibody (HCV Ab).
Sixty-eight (16.5%) patients had one or more EHPM.
The most frequent EHPM was gastric cancer (n=32) in this cohort.
No statistical significance was observed in the distribution of viral infection and incidence of entire EHPM.
However, HCV Ab, HBs Ag, and negative status for both were correlated with the frequency of gastric (P=0.0194), urinary tract (P=0.0067), and breast cancer (P=0.0036), respectively.
Infection of Helicobacter pylori was investigated by immunohistochemistry in gastric EHPM and resulted that 20 out of 21 analyzed cases were negative for Helicobacter pylori.
Although it should be verified by well-designed large cohort studies, the current results suggested correlation between HCV infection and gastric cancer, HBV infection and urinary tract cancer and viral hepatitis-free status and breast cancer in HCC patients.
American Psychological Association (APA)
Kai, Keita& Miyoshi, Atsushi& Kitahara, Kenji& Masuda, Masanori& Takase, Yukari& Miyazaki, Kohji…[et al.]. 2012. Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476269
Modern Language Association (MLA)
Kai, Keita…[et al.]. Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-476269
American Medical Association (AMA)
Kai, Keita& Miyoshi, Atsushi& Kitahara, Kenji& Masuda, Masanori& Takase, Yukari& Miyazaki, Kohji…[et al.]. Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476269