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The Performance of Quantiferon TB Gold In-Tube as a Screening Tool in Paediatric Rheumatology prior to Initiation of Infliximab : A Single Centre's Experience
Joint Authors
Maritsi, Despoina N.
Eleftheriou, Despina
Brogan, Paul A.
al-Obadi, Muthana
Dixon, Garth L. J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Patients with autoimmune diseases and latent tuberculosis infection (LTBI) are at risk of developing catastrophic tuberculosis disease following infliximab treatment.
Quantiferon-TB gold in-Tube (QTB) has proven a more accurate screening tool than tuberculin skin test (TST) in adult populations.
Objectives.
To assess the utility and validity of QTB in children, prior to treatment with infliximab.
Methods.
Retrospective cohort of patients started on infliximab following endorsement of QTB as a screening tool by the NICE guidelines in 2006.
Results.
Twenty three patients (12 females and 11 males) were included in the study.
A chest radiograph (CXR) and QTB was performed prior to starting infliximab.
Fourteen patients had a recorded negative TST result.
One patient had a positive QTB while two had indeterminate results.
Their CXRs were not suggestive of TB and TSTs were negative.
The patients with indeterminate results were started on infliximab and had regular clinical assessment for TB disease.
Repeat QTB was negative in one while remained indeterminate in the other.
None of our 23 patients developed TB.
Conclusion.
QTB is a useful screen tool for LTBI.
Indeterminate results warrant careful assessment and re-evaluation, but should not preclude from initiation of anti TNF treatment.
American Psychological Association (APA)
Maritsi, Despoina N.& al-Obadi, Muthana& Brogan, Paul A.& Eleftheriou, Despina& Dixon, Garth L. J.. 2011. The Performance of Quantiferon TB Gold In-Tube as a Screening Tool in Paediatric Rheumatology prior to Initiation of Infliximab : A Single Centre's Experience. ISRN Rheumatology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-476943
Modern Language Association (MLA)
Maritsi, Despoina N.…[et al.]. The Performance of Quantiferon TB Gold In-Tube as a Screening Tool in Paediatric Rheumatology prior to Initiation of Infliximab : A Single Centre's Experience. ISRN Rheumatology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-476943
American Medical Association (AMA)
Maritsi, Despoina N.& al-Obadi, Muthana& Brogan, Paul A.& Eleftheriou, Despina& Dixon, Garth L. J.. The Performance of Quantiferon TB Gold In-Tube as a Screening Tool in Paediatric Rheumatology prior to Initiation of Infliximab : A Single Centre's Experience. ISRN Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-476943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476943