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Evaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock
Joint Authors
Lambermont, Bernard C.
Revie, James A.
Shaw, Geoffrey M.
Stevenson, David
Desaive, Thomas
Kolh, Philippe
Chase, J. Geoffrey
Pretty, Chris J.
Ghuysen, Alexandre
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-25
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Introduction.
The accuracy and clinical applicability of an improved model-based system for tracking hemodynamic changes is assessed in an animal study on septic shock.
Methods.
This study used cardiovascular measurements recorded during a porcine trial studying the efficacy of large-pore hemofiltration for treating septic shock.
Four Pietrain pigs were instrumented and induced with septic shock.
A subset of the measured data, representing clinically available measurements, was used to identify subject-specific cardiovascular models.
These models were then validated against the remaining measurements.
Results.
The system accurately matched independent measures of left and right ventricle end diastolic volumes and maximum left and right ventricular pressures to percentage errors less than 20% (except for the 95th percentile error in maximum right ventricular pressure) and all R2>0.76.
An average decrease of 42% in systemic resistance, a main cardiovascular consequence of septic shock, was observed 120 minutes after the infusion of the endotoxin, consistent with experimentally measured trends.
Moreover, modelled temporal trends in right ventricular end systolic elastance and afterload tracked changes in corresponding experimentally derived metrics.
Conclusions.
These results demonstrate that this model-based method can monitor disease-dependent changes in preload, afterload, and contractility in porcine study of septic shock.
American Psychological Association (APA)
Revie, James A.& Stevenson, David& Chase, J. Geoffrey& Pretty, Chris J.& Lambermont, Bernard C.& Ghuysen, Alexandre…[et al.]. 2013. Evaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-476967
Modern Language Association (MLA)
Revie, James A.…[et al.]. Evaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-476967
American Medical Association (AMA)
Revie, James A.& Stevenson, David& Chase, J. Geoffrey& Pretty, Chris J.& Lambermont, Bernard C.& Ghuysen, Alexandre…[et al.]. Evaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-476967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476967